A.N. Belousov, V.G. Rykov


Our nanotechnology for synthesis of magnetic fluids has enabled both successful use of magnetite nanoparticles (MNPs) in biology and medicine, and a detailed study of their effect on biological systems in a living organism [1]. It should be emphasized that the size of the particles of the magnetite, which we obtain, is within 6-12 nm. In the process of a clinical-experimental study on homeostatic systems of the inner medium in a living organism we have revealed a high degree of adaptability of MNPs administered in different ways.

Interest to the processes which take place in the organism as a response to administration of MNPs is generated by the fact that the obtained clinical-laboratory effect is identical to the influence of an external magnetic field on the living organism. Parallelism of the main effects in cell response to the constant magnetic field and MNPs is observed. It is generally known that the effect of a constant external magnetic field on a cell reduces the latters energy demands and creates favorable conditions of existence for a cell with disturbed homeostasis. Influence of a constant magnetic field on cell membranes and organelle a results in a change of the membrane potential, concentration of ions on the outer and inner surfaces of the membrane as well as it changes conditions for functioning of a normal cell and particularly a cell with pathological changes [2]. Our studies of cell ultrastructure in livers, lungs and kidneys of animals did not reveal any destructive changes of submicroscopic architectonics of organelles in the examined organs after intravenous injections of MFPs. On the contrary, all reconstructions testified to an increase in adaptive-accommodative potentials of organelles and a higher extent of reparative processes at the level of membranes and macromolecules.

Clinical blood analysis revealed parallelism of such effects as increases in the amount of hemoglobin, erythrocyte and lymphocyte counts, a moderate decrease of leukocytes, a delayed erythrocyte sedimentation rate, normalization in the blood clotting time.

While studying the response of immunological links we observed similar effects in stimulation of the phagocytes activity of leukocytes and macrophages both in vitro and in vivo, as well as in the total effect of the external magnetic field on the organism. According to Sherstneva O.S., an external magnetic field increases the phagocyte activity of leukocytes both in vitro and in vivo. Sosunov A.V. has reported that a weak magnetic field of 1.6 kA/m increases the phagocyte activity of leukocytes too.

Consequently, we have revealed a similarity in main responses of homeostatic systems of the organism to administration of MNPs and to the effect of the external constant magnetic field. It is based, first of all, on the biological influence of the constant magnetic field which surrounds every subdomainal particle of the magnetite. Effects of MNPs, administered into the organism, on cellular and subcellular structures are undoubtedly caused by the influence of the constant magnetic field. Due to reaction of magnetization of the cellular and extracellular fluids, particles of the magnetite change polarization and permeability of the cell membranes in the organism.


1. Belousov A.N.(1997) The method of producing magnetic liquid for transport and retention of medicines in the organism. The State patent №14817А UA A61N2/00/(Ukraine).Bull. 2, 3 pp.

2. Деген �?.Л. Механизм влияния на пациента магнитных полей, применяемых с терапевтической целью. // В кн. Магнитное поле в медицине. - Фрунзе, 1974. - С.172.


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